About Conolidine alkaloid for chronic pain
Most not long ago, it has been determined that conolidine and the above mentioned derivatives act about the atypical chemokine receptor three (ACKR3. Expressed in equivalent places as classical opioid receptors, it binds to a wide array of endogenous opioids. As opposed to most opioid receptors, this receptor acts for a scavenger and won't activate